Multi-Omics for Mothers & Infants

A hospital-based cohort of pregnant women, GARBH-Ini ((interdisciplinary Group on Advanced Research on BirtH outcome - DBT India Initiative) has been established at the civil hospital atGurugram, Haryana, India by Translational Health Science and Technology Institute (THSTI) withthe hypothesis that risk stratification of pregnant women using time series multidimensional dataon clinical, epidemiological, genetic, proteomic, metabolomic and ultrasonographic attributes willfacilitate the development of an effective algorithm for early prediction and timing of intervention ofPTB with support from the Dept. of Biotechnology, Govt. of India.

The GARBH-Ini Cohort has joined the Multi-Omics for Mothers and Infants (MOMI) Consortium, which is an international group of leading experts on maternal, newborn, and child health, and innovative ‘omics’ technologies working together to accelerate solutions for adverse pregnancy outcomes and optimize health for mothers and infants in low-and-middle- income countries.

The specific objective is to carry out extensive omics assays (genetics, metabolome, proteome etc.) on samples collected in different studies across low and middle-income countries (AMANHI cohorts in South East Asia and Africa and GAPPS cohort in Africa) to look in-depth at the clinical and biological risk factors and predictors in preterm birth, stillbirth, preeclampsia and IUGR.