A potential off the shelf tubular scaffold for vascular tissue engineering
USP: Fluoroalcohols are commonly used to electro spin biological polymers and are expensive and not environment friendly. We have Electrospun the blend using a benign cost effective solvent patent granted that preserves the biological motifs that promote cell adhesion and migration. The economical solvent can bring down the manufacturing cost. Moreover there are no blended biological & synthetic scaffolds in the small vessel diameter category.
- Innovator's Name
- Product/Technology Description
Sri Ramachandra Institute for Higher Education and Research
- Product Name: A potential off the shelf tubular scaffold for vascular tissue engineering
- Product Title: Small diameter tubular scaffold 2mm , a Blend of synthetic and natural polymers was fabricated by electrospinning. SEM analysis confirmed scaffolds were composed of nanofibers and the tensile properties and suture strength of scaffolds were evaluated. Biocompatibility of material blend was evaluated as per ISO 10993-5 and 10993-6 and showed no mortality, morbidity, no inflammatory reaction erythema and edema , no signs of infection any discharge and no scratching observed in implant group when compared to control animals. Endothelial cells were cultured on the lumenal surface in vitro over a 2 week period and showed proliferation and viability. Anti coagulant coating of scaffold was also evaluated and showed efficient prevention of blood coagulation in vitro.
- Description:
- Unique Selling Point: Fluoroalcohols are commonly used to electro spin biological polymers and are expensive and not environment friendly. We have Electrospun the blend using a benign cost effective solvent patent granted that preserves the biological motifs that promote cell adhesion and migration. The economical solvent can bring down the manufacturing cost. Moreover there are no blended biological & synthetic scaffolds in the small vessel diameter category.
