Monosodium glutamate-inducible Pichia pastoris yeast expression system
USP: An innovative, patented yeast expression system for recombinant protein production in Pichia pastoris
- Innovator's Name
- Product/Technology Description
Indian Institute of Science Bangalore
- Product Name: Monosodium glutamate-inducible Pichia pastoris yeast expression system
- Product Title: The methylotrophic yeast, Pichia pastoris Komagataella phaffi is widely used for the production of recombinant proteins of academic and commercial importance. Methanol-inducible alcohol oxidase promoter is widely used for this purpose. We have developed a novel expression system in which recombinant protein production can be induced by monosodium glutamate, the USFDA-approved flavour agent. The proof of principle has been demonstrated by expressing SARS CoV2-RBD in shake flasks with BIRAC funding. Indian patent has been granted. We have filed U.S. patent applicaiton National phase . Looking for an industrial forward for validation of our expression system in a fermenter/Bioreactor.
- Description:
- Unique Selling Point: An innovative, patented yeast expression system for recombinant protein production in Pichia pastoris
